The Science

Clinical Evidence Library

Independent clinical and laboratory research on adhesives, extended-wear systems, oral appliances and advanced cleansing technologies.

Long-Wear Denture Adhesive Performance

Extended-wear adhesion • Retention • Comfort • Function
Randomized Trial

Biocompatibility and Effectiveness of a Novel Olive-Oil Denture Adhesive (Azevedo et al., 2021)

J Clin Exp Dent • 2021
Multicenter, randomized, placebo-controlled trial
Demonstrated longer denture hold time, improved comfort scores, and no significant mucosal irritation—supporting effective, safe extended-wear adhesion.
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In Vitro Study

Removal of Denture Adhesives from PMMA/Polyamide Denture Bases (Polychronakis et al., 2021)

J Appl Oral Sci • 2021
Found that modern adhesives strongly adhere to denture bases, reinforcing the importance of proper cleansing between long-wear applications.
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Daily Denture Adhesives & Patient Tolerability

Zinc-free daily adhesives • Comfort • Oral & dermatologic safety
Clinical Study

Clinical & Patient Satisfaction Evaluation of Olive-Oil-Based Adhesive (Mascolo et al., 2019)

EC Dental Science • 2019
Over 80% of patients improved in at least one functional or comfort parameter—supporting strong retention with a zinc-free adhesive.
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Dermatology Report

Clinical Application Study Under Dermatological Control (Dermatest)

Dermatest GmbH • 2017
No pathological skin or mucosal reactions were observed, confirming excellent tolerability.
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Dermatology Report

Dermatological Application Test on Denture Adhesive Creams (Dermatest)

Dermatest GmbH • 2017
Reported long adhesion times, fresh taste, and strong comfort with no irritation.
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Denture & Appliance Cleansers – Biofilm Control

Biofilm disruption • Candida control • Appliance hygiene • Odor reduction
In Vitro Study

Sanitization Effectiveness of a Denture-Cleaning Tablet (Glass et al., 2004)

Quintessence Int • 2004
A single effervescent-tablet treatment eliminated Candida, key bacteria, and HSV-1 virus.
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In Vitro Study

Antimicrobial Effect of Cleansing Tablet on Mouthguards (Glass et al., 2011)

JADA • 2011
Regular cleansing significantly reduced microbial contamination on mouthguard materials.
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Biofilm Study

Effect on Single- and Mixed-Species Biofilms (Coenye et al., 2008)

J Appl Microbiol • 2008
Daily use produced marked reduction in Candida and multispecies biofilm on acrylic.
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Clinical Study

Cleanser Use in Denture Stomatitis Patients (Silva-Lovato et al., 2010)

J Appl Oral Sci • 2010
Greater reduction of denture biofilm and Candida with clinical improvement vs controls.
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In Vitro Study

Antimicrobial Effect on Acrylic Appliances (Fathi et al., 2015)

J Contemp Dent Pract • 2015
NitrAdine tablets significantly reduced S. mutans and Candida on acrylic appliances.
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Biofilm Study

Denture Cleansing Tablet vs Candida Biofilm (Decelis et al.)

In-vitro Lab Study
Repeated exposure produced major decreases in Candida biofilm on denture acrylic.
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In Vitro Study

Antimicrobial Action on Denture Base Biofilms (Coimbra et al., 2016)

Braz Oral Res • 2016
Medical Interporous cleanser showed strongest antimicrobial effect vs other methods.
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In Vitro Study

Cleanser Efficacy on Mixed-Species Biofilms (Coimbra et al., 2021)

Braz Dent J • 2021
Effervescent tablet showed superior reduction of bacterial & Candida biofilms.
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In Vitro Study

Effect on Multispecies Denture Biofilms (Ribeiro et al., 2022)

Laboratory Assessment • 2022
Oxidizing-agent tablets disrupted mature multispecies biofilms more effectively than brushing.
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Clinical Study

Cleanser Effect on Denture Stomatitis (Vento-Zahra et al., 2011)

Clinical Evaluation • 2011
Reduced inflammation & plaque scores—indicating effective stomatitis-related biofilm control.
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Cytotoxicity & Antimicrobial

Antimicrobial Action on Candida Biofilms (Araujo et al., 2021)

Lab Study • 2021
Strong antifungal activity while maintaining acceptable cytotoxicity levels.
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Biofilm Study

Effervescent Tablet Action on RPD Biofilms (Vasconcelos et al., 2020)

Experimental Study • 2020
Efficiently reduced biofilm on denture alloy/acrylic without damaging materials.
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